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* **Portrait** : The standard portrait position enables the camera to place the subject in the center of the image. However, you can also adjust the image’s top and/or bottom and left and right positions, including changing their width.
* **Landscape** : The standard landscape position enables the camera to place the subject in the center of the image. However, you can also adjust the image’s top and/or bottom and left and right positions, including changing their width.
* **Square, landscape** : The digital camera’s default picture-taking mode is called square or landscape. When you’re shooting a square picture, the camera automatically positions the subject horizontally and vertically in the center of the frame. To get a landscape orientation instead, you can choose this option from the Shooting Menu and the camera will adjust the subject’s horizontal and vertical positions to center it in the frame. (When you take a landscape picture, you don’t have to manually crop the edges of the picture after you take it.)
* **Portrait, square** : This picture-taking mode works the same way as portrait, except that the camera doesn’t turn the subject’s face vertically.

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Adobe Photoshop is a powerful image editor. When we need to edit images, we often want to retouch them to improve their quality. Photoshop is one of the popular image editing software programs available today. In this article, we’ll guide you through the Photoshop interface and how to use it to edit images.

This article is a guide on how to use Photoshop. This guide is for those who use Photoshop on a daily basis. It doesn’t cover the basics and assumes that you have a basic knowledge of Photoshop. If you are looking to learn Photoshop, we recommend studying our tutorial on how to use Adobe Photoshop.

We’ll cover the following in this article:

Our Photoshop beginner’s guide: The interface and tools Photoshop often hides a ton of powerful features from you until you have used the program for a while. Luckily, the Photoshop interface is fairly intuitive. Here, we’ll go over the basics and show you some of the tools you’ll be using. First, you can navigate through your images with the Thumbnail panel on the left side. This panel also contains the File menu which contains several options for quickly navigating through your files. The other big part of the Photoshop interface is the Layers panel on the right. We will cover some of the tools that are available in this panel later on. When you have clicked on a thumbnail, the contents of the image will be displayed on the canvas. The canvas is where all the editing work takes place. It contains a variety of tools for manipulating the colors, shapes and textures. To edit the contents of your image, click on the tools icon in the toolbar to select an editing tool. The tools we will cover are as follows:

Colors: This tool lets you adjust the color of your image. You can adjust the colors by using the sliders that are marked with a blue color.

Hue-Saturation: This tool lets you adjust the color of your image by selecting the color you want to modify and using the slider above it.

Curves: This tool lets you modify the colors of your image and adjust the brightness.

Straighten: This tool helps you to straighten a curved image to make it look more in-line.

Rotate: This tool lets you rotate your image.

Bulge/Bump Map: This tool lets you add texture and color to your image by using a separate texture map.

Contract: This tool lets you reduce the size of your image
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High-threshold Ca2+ channel antagonist, mibefradil, normalizes pathological parameters in a rat model of attention deficit hyperactivity disorder.
Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder characterized by a high prevalence of symptoms of inattention and hyperactivity/impulsivity in children and adults. When ADHD is not controlled by medications, other treatments, such as physical therapy, should be implemented. The aim of this study was to investigate the therapeutic effect of a high-threshold voltage-dependent Ca2+ channel antagonist, mibefradil on the neurological, biochemical, and molecular effects caused by the inattentive behaviour in a well-validated animal model of ADHD. A pharmacological model of ADHD was produced in male rats by a combination of methylphenidate and amphetamine. Methylphenidate induced hyperactivity, thus resembling the hyperactivity disorder observed in patients with ADHD. Methylphenidate- and amphetamine-treated animals exhibited less attention and less locomotor activity than controls. The hyperactivity induced by methylphenidate and amphetamine was accompanied by a significant increase in brain Ca2+ uptake, as measured in vitro. Mibefradil reversed the behavioural, biochemical, and molecular effects caused by methylphenidate and amphetamine, thus resembling the neuroprotective effects of a Ca2+ channel antagonist. However, mibefradil did not attenuate the hyperlocomotor response caused by amphetamine. These results suggest that the high-threshold Ca2+ channel antagonist, mibefradil, might be a potential medication of choice for ADHD.

Heartbreaking: Police Harassing a Man with a “Patch” on His Forearm – bdr

======
jchrisa
> Police could see his helmet so they asked him a question. This, he said,
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> tattoo says ‘#pickup.’” The officer said they were looking for someone else.

I have that same t-shirt, and I’m glad they refused to drop their ticket,
because it was good the guy got a chance to react with a little

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cytosine. The sample was amplified using sequencing primers and MiSeq sequencing adapters (Illumina).

Sequencing reads were mapped to the human genome using the Bowtie alignment software [@pone.0068205-Langmead1], [@pone.0068205-Langmead2]. The Bowtie alignments were scored for discordant paired reads using the BOWtie software module within SamTools [@pone.0068205-Li1], [@pone.0068205-Harrower1]. The discordant paired reads were then filtered for read pairs with alignments to single sites and which reported sequencing cycles with a mean of \

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